BCR and myeloproliferative neoplasm: As sketched in Fig. 7, the BCR-ABL1 gene translocation resulting in a constitutively active BCR-ABL1 TK renders normal hematopoiesis incipiently into a moderate myeloproliferative neoplasm (CML-CP) that is characterized by increased white blood cell counts including appearance of more or less undifferentiated BCR-ABL1-positive myeloid precursors in the PB of patients.