ISG15 and infection: Similar to our TCS data in Fig. 6G, the total error rate in viral nsp10 was significantly increased(Two-way ANOVA with Tukey’s multiple comparison test) in groups where treatment wasinitiated prior to (-2 hours, median error rate = 10.5 errors/10,000 bases, P < 0.0001)and up to 24 hours post infection (12 hours, median error rate = 8.2 errors/10,000 bases,P < 0.0001 ; +24 hours, median error rate = 5.4 errors/10,000 bases, P = 0.0003) butthe error rates in ISG15 remained at baseline for all groups (Fig. 7H).