CADPS and Nager acrofacial dysostosis: The previous study showed that UNC-31, C. elegans ortholog of calcium-dependent activator protein required for the secretion of neuropeptide (Speese et al., 2007) and EAT-4, C. elegans homolog of sodium-dependent inorganic phosphate cotransporter required for glutamatergic transmission (Lee et al., 1999) function in AFD to regulate the excitatory-inhibitory balance onto AIY (Nakano et al., 2020).