Anti-MDA5 autoantibody-positive JDM patients show near-complete overlap with SAVI (PCA-B, Fig. 2b), in contrast to anti-NXP2 and anti-TIF1 autoantibody-positive JDM, and the MSA-negative groups, which overlap more with SAVI than CANDLE, but to a lesser degree (PCA-C, PCA-D, Fig. 2c, d; PCA-E, Additional file 1: Figure S2). The gene discussed is MORC3; the disease is juvenile dermatomyositis.