CUL7 and central nervous system cancer: The expression level of CUL7 was significantly higher (> median value) in the mesenchymal subtype than in the proneural subtype (Fig. 1b; Fig. S1b; Table 1), and the ROC curve further showed the sensitivity of CUL7 as a marker to discriminate between the mesenchymal subtype and the non-mesenchymal subtype glioma patients (Fig. 1c).