CUL7 and hepatocellular carcinoma: Furthermore, the upregulation of CUL7 has been revealed in multifarious malignant tumours, such as hepatocellular carcinoma [11], epithelial ovarian cancer [12], lung cancer [13], breast cancer [14], and choriocarcinoma [15]; thus, there is a good chance that CUL7 plays an important role in tumour progression.