Based on the topology analysis, the top 5 hub proteins (according to the degree) were PRKCA (DC, 6.0; BC, 743.0; CC, 0.02647585), InaD-like protein (INADL) (DC, 5.0; BC, 319.0; CC, 0.026176158), cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) (DC, 5.0; BC, 333.0; CC, 0.026111504), myosin heavy chain type II isoform A (MYH9) (DC, 5.0; BC, 309.0; CC, 0.026222536) and natriuretic peptide receptor A/guanylate cyclase A (NPR1) (DC, 5.0; BC, 77.0; CC, 0.025819957). This evidence concerns the gene PRKAR1A and breast cancer.