In another animal study, it was reported that administration of a lower dose combination of alendronate (ALD) and ATV (0.01 mg/kg + 0.3 mg/kg, respectively) reduced periodontal inflammation, ABL and secretion of matrix metalloproteinases (MMP-1, MMP-2, MMP-3, and MMP-9) in ligature-induced periodontitis in rats [74]. This evidence concerns the gene MMP1 and periodontitis.