However, ARDS patients with rs3743631 GG genotype(vs AA and AG genotypes) showed lower S1P levels (median 222.73 nmol/L, IQR126.69–318.61 nmol/L vs median 314.81 nmol/L, IQR 240.10–436.90 nmol/L; P = 0.004).Similar results were obtained in the patients with rs907045 AA or TA genotype (AA andTA vs TT, median 281.31 nmol/L, IQR 201.69–342.93 nmol/L; vs median 335.73 nmol/L,IQR 235.20–450.46 nmol/L; P = 0.035). The gene discussed is MBTPS1; the disease is acute respiratory distress syndrome.