NLRP3 and early-onset autosomal dominant Alzheimer disease: As such, NLRP3 activity is receiving growing interest as a contributor to various CNS conditions in which glia-mediated neuroinflammation has been associated with disease progression such as Alzheimer’s disease, stroke, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and pneumococcal meningitis [62–68].