In additional assessments of cardiac hypertrophy within this experimental cohort, RV tissues were stained with anti-CD31 antibody (Supplemental Figure 5B) which enabled autologous quantitation of both CD31 positive vascular endothelial cells, a measure of vascularization/angiogenesis, and also of cardiomyocyte cross-sectional area, a measure of cardiac hypertrophy. This evidence concerns the gene PECAM1 and cardiac hypertrophy.