The IMPROVE study evaluated patients’ preference for either combined antihormonal therapy (everolimus + exemestane, Eve+Exe) or combined chemo- and anti-angiogenic therapy (capecitabine + bevacizumab, Cap+Bev) in postmenopausal patients with advanced HR-positive, HER2-negative BC and indication for first-line chemotherapy or endocrine therapy after failure of ≥1 standard non-steroidal aromatase inhibitor therapy. Here, CYP19A1 is linked to breast cancer.