In proliferative diabetic retinopathy (PDR) stage, hypoxic retinal tissue leads to liberation of angiogenic agents such as vascular endothelial growth factor (VEGF) which plays a major role in the development of retinal and optic disc neovascularization, such neo vessels can bleed at any time and cause vitreous hemorrhage (VH). This evidence concerns the gene VEGFA and vitreous hemorrhage.