Secondly, for kidney diseases, increased levels of LRG1 was identified in chronic kidney disease [25], sepsis patients with acute kidney injury [26], classical galactosemic patients with subclinical kidney insufficiency [27], children with idiopathic nephrotic syndrome [28] by using a plasma/serum/urine proteomics approach, but the proteomics studies just revealed a hint that LRG1 might be associated with kidney diseases. This evidence concerns the gene LRG1 and chronic kidney disease.