Here, we further displayed that higher levels of IFN-γ and lower levels of IL-10 in Tregs depletion mice infected with P.y17XL on day 3 p.i. were noted (Fig. 4); Although all mice died, the lifetime was extended by 2 days compared to normal infection mice (Fig. 3), perhaps correlated with the disppearance of Tregs inhibition of Th1 response. The gene discussed is IFNG; the disease is infection.