CREB1 and endometriosis: CREB1 is a potential transcription factor of BRAF. Compared with normal endometrial tissue, the mRNA expression levels of BRAF and CREB1 are significantly upregulated in endometrial tissues of patients with endometriosis; thus, CREB1 can increase the expression of BRAF and regulate cell proliferation by binding directly to BRAF in such women [29].