INS and diabetes mellitus: Mahmoud et al. (2019) in their comprehensive review of the effects of diabetes mellitus (DM) on MSC function, report a total of 5 studies that assess the functional capacity of bone marrow-derived MSCs from people with T2DM [13], including two studies that focus on the differentiation of MSCs into insulin producing cells and three studies that assess outputs relating to MSC proliferative or differentiation capacity.