Whereas the 326Ser/Cys OGG1 and the 324Gln/His as well as the 324His/His MUTYH genotypes were associated with an increased CRC risk, the decreased efficiency of DNA repair was correlated with the 399Gln/Gln XRCC1 and the 324His/His MUTYH genotypes occurrence in CRC patients. Here, OGG1 is linked to colorectal carcinoma.