NOTCH1 and renal cell carcinoma: Here, we confirmed the prognostic relevance of trait-associated genes in the context of predicting recurrence and survival in early-stage RCC and identified its association with ECM remodeling, focal adhesion, mRNA translation, PI3K/AKT signaling, NOTCH1 pathway, WNT pathway, and cell cytoskeleton, enabling an in-depth understanding of noninvasive RCC biology using CT images and increasing the potential of radiogenomics maps.