Importantly, we found that FGFR1 and FGFR3 target genes were enriched in OUTER_Energy_HIST- and INNER_Min_HIST-associated genes, and RCC characterized by OUTER_Energy_HIST and INNER_Min_HIST could be effectively targeted by erlotinib, lapatinib, and nilotinib based on drug–target relationships using kidney cell lines from the CCLE dataset [22]. The gene discussed is FGFR3; the disease is renal cell carcinoma.