NF1 and malignant peripheral nerve sheath tumor: Collectively, these studies identified frequent somatic loss of NF1, CDNKN2A, TP53, and genes from the PRC2 complex, specifically SUZ12 and EED. A variety of other genes have been implicated in the progression from benign to malignant peripheral nerve sheath tumors, including candidate driver genes such as EPC1, CHD4, AEBP2 and ATRX. These genes have been implicated in MPNST primarily because of their critical interaction with molecules in the PRC2 complex [11].