The overarching focus of the GeM Consortium is to facilitate the collection and sharing of molecular and clinical data on rare NF1-related malignant and pre-malignant tumors related to MPNST, such as atypical neurofibromatous neoplasms of uncertain biological potential (ANNUBP), and, as a lower priority, sporadic MPNST, with the goal of facilitating more rapid progress in translational research to improve clinical outcomes. Here, NF1 is linked to malignant peripheral nerve sheath tumor.