For example, fructose-bisphosphate aldolase (ALDO), a sensor of glucose availability, when occupied by its substrate, fructose-1,6-bisphosphate, cannot promote AMPK activation, whereas ALDO free of FBP stimulates the formation of a lysosomal complex composed of AMPK, V-ATPase, Ragulator, AXIN, and LKB1 kinase tumor suppressors; this complex is required for AMPK phosphorylation and activation by LKB1 [226]. The gene discussed is STK11; the disease is neoplasm.