For example, SIRT3 over-expression has been implicated in kidney cancer growth inhibition and maintaining mitochondrial homeostasis, as well as modulating ROS production to sensitize biomolecules and cells to oxidative damage [64], whereas low SIRT3 level is associated with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma (HCC) [65]. The gene discussed is SIRT3; the disease is hepatocellular carcinoma.