Systems biology approach with the use of AMPK/HIF-1/ROS circuit allowed for the prediction of three stable metabolic phenotypes of cancer cells: (i) glycolysis phenotype with high HIF-1 and low AMPK activities, (ii) OXPHOS phenotypes with high AMPK and low HIF-1 activities, and (iii) hybrid glycolysis/OXPHOS phenotype with both high HIF-1 and AMPK activities [239]. This evidence concerns the gene HIF1A and cancer.