RPS6KB1 and familial pancreatic carcinoma: Moreover, activation of mTOR complex 1 and ribosomal protein S6 kinase-β1 (mTORC1/S6K1)-mediated pathway have been observed to regulate c-Myc to promote uptake of glutamine and to stimulate its catabolism via up-regulation of GLS in pancreatic cancer cells through modulating phosphorylation of eukaryotic translation initiation factor eIF4B, which is crucial to unwind its 5’-untranslated region (5’UTR) [193].