For example, HIF-1α expression has been reported to correlate positively with those of both GLUT1 and LDH-5 at both mRNA and protein levels in human gastric and ovarian cancers, and this was found to be associated with tumor size, depth of invasion, distant metastasis, clinical stage, and differentiation status [83,84]. This evidence concerns the gene SLC2A1 and ovarian carcinoma.