Analysis of the expression of SRY-Box transcription factor 2 (SOX2) overlapping transcript (Sox2ot)—a long non-coding RNA (lncRNA)—derived from exosomes of highly invasive PDAC cells in plasma samples revealed that the plasma exosomal Sox2ot expression was high and correlated with TNM classification of malignant tumor stage and overall survival rate of PDAC patients. This evidence concerns the gene SOX2 and cancer.