JAG1 and neoplasm: Although specific molecular events governed by miR-26 were not fully described, miR-26a was reportedly downregulated in tumor tissues and prevented EMT through direct inhibition of connective tissue growth factor (CTGF), rho-associated, coiled-coil-containing protein kinase 1 (ROCK1), enhancer of zeste homolog 2 (EZH2), and Jagged-1, which led to inactivation of the Jagged-1/Notch and TGFβ1/SMAD pathways [94,95,96,97,98].