Although downstream transcription factors including β-catenin, Zinc finger protein SNAI1 (SNAIL)/Zinc Finger Protein SNAI2 (SLUG), Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), and Twist-related protein 1 (TWIST) govern EMT-related gene expression, recent studies suggest that controlling the expression and function of these factors does not completely inhibit EMT induction in tumor cells [6,7,8]. Here, TWIST1 is linked to neoplasm.