STAT3 and cancer: Accordingly, under our experimental conditions, we found that phosphorylation of STAT3 at tyrosine 705 was promoted by doxorubicin in both cancer and noncancerous cells, being markedly overexpressed in Mz-ChA-1 cells (about a 10-fold higher expression with respect H69 cholangiocytes), whereas the combination with β-caryophyllene hindered its activation especially in H69 cells, achieving the normal expression in the control (Figure 14A,B).