These encompass seven protein-coding genes (FAM19A4, GHSR, MAL, PHACTR3, PRDM14, SST and ZIC1)—of which, the CpG islands are methylated in bladder cancer—as well as two miRNAs (miR-129 and miR-935) with promoter regions that are also known to be methylated in bladder cancer [6]. The gene discussed is PHACTR3; the disease is urinary bladder cancer.