H&E stains of human biopsy samples of the tumor border showed long, well-formed extensions from the tumor into the parenchyma, shown histologically and schematically in Figure 2B. Immunohistochemistry on human biopsy samples at the tumor border revealed collagenous structures positively stained for collagen VI, and CCL5 (Figure 2C). This evidence concerns the gene CCL5 and neoplasm.