Genes previously associated with EBV infection of B cells CD28 [29] and CXCL10 [30, 31] were up-regulated in EBV-infected groups, whereas the PTLD-associated transcripts IL6 [25] and TNFSFR8 (CD30) [32] were up-regulated specifically in the B cells from EBV-infected FK506-treated animals (Fig 4C). This evidence concerns the gene CD28 and Epstein-Barr virus infection.