When we analyzed the expression of EBV latent transcripts associated with the transforming latency III (Cp/Wp-EBNA1, EBNA2) and II/III (LMP1, LMP2A), we observed significantly increased expression levels of all of these viral oncogenes in B cells of FK506-treated compared to untreated huNSG-A2 mice whereby the highest levels were noted among tumor-bearing mice (Fig 3D). The gene discussed is CP; the disease is neoplasm.