In an animal study, Mohammadi-Kordkhayli et al. [19] evaluated the impact of vitamin D supplementation on IL-27 expression levels in the experimental autoimmune encephalomyelitis (EAE) and proved that compared to a control group, the expression level of IL-27 P28 and IL-27 EBI3 was powerfully up-surged in vitamin D-treated group. The gene discussed is IL27; the disease is experimental autoimmune encephalomyelitis.