Accordingly, the aim of this retrospective study was to explore lipid profiles in children diagnosed with ALL prior to onset of therapy, and its potential association with BMI, early therapy response, on-therapy hyperlipidemia and/or steroid- and asparaginase-associated toxicities; thromboembolism, osteonecrosis and pancreatitis. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.