The high expression of NTN1, NTN3, and NTNG1 is also sensitive to MS-275 (HDAC inhibitor), RG-108 (DNA methyltransferase inhibitor), and CUDC-101 (HDAC inhibitor, EGFR inhibitor, and HER2 inhibitor), which inhibit tumor by affecting epigenesis. Here, NTN3 is linked to neoplasm.