It is important to note that in the group with low deuterium content we observed an increased production of obesity-protective adipokines (LEPTIN and ADIPONECTIN) and IL-6 (this cytokine increases the production of LEPTIN in adipocytes), and decreased production of pro-inflammatory TNF-α, IL-8, MCP-1, IP-10, ADIPSIN (inhibits the lipolysis) and IL-10 (inhibits the thermogenesis and browning). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.