Compared to PVL, the upstream regulator analysis revealed the activation of TGF-β, KRAS, ERK1/2, IL1, and INS at early phase and Vegf, HGF, Interferan alpha, IL6, IL1B, and NFKB at the later regeneration phase after ALPPS and PH. This evidence concerns the gene IL6 and periventricular leukomalacia.