BRCA1 and breast cancer: Effect sizes within the range known for breast cancer predisposition by pathogenic variants of BRCA1 and BRCA2 (ORs > 8)30 were observed at rs182352457_A (P = 8 × 10−9, OR = 8.4), rs188140481_A (P = 2 × 10−12, OR = 8.5), and rs138042437_G (P = 3 × 10−12, OR = 9.1).