To assess the functional relevance of the direct regulation of NMNAT on the abnormal aggregation of pTau in vivo, we examined the protective capability of Nmnat in Drosophila tauopathy models by overexpressing human wild type (TauWT) or pathogenic Tau (TauR406W) in the visual system using a photoreceptor-specific driver GMR-GAL4 (Ali et al., 2012). Here, LGALS4 is linked to tauopathy.