One of Notch ligand, JAG2 appeared to exert several carcinogenesis, endometrial cancer (Townsend et al., 2019), colorectal cancer.(He et al., 2016), myeloma.(Ghoshal et al., 2009; Houde et al., 2004), pancreatic cancer (Mullendore et al., 2009), and breast cancer (Xing et al., 2011). Here, JAG2 is linked to familial pancreatic carcinoma.