MAPT and Alzheimer disease: There were significant associations reported between AD PRS and the following: increased CSF tau and phosphorylated tau [9]; CSF Aβ [10]; lower Aβ42/Aβ40 [49]; higher t-tau/Aβ42 and higher p-tau/Aβ42 ratio [25, 49]; positive Aβ PET [33]; total PET/CSF amyloid load and tau load [35]; postmortem soluble Aβ42 and λ-secretase activity [10]; postmortem amyloid plaques and neurofibrillary tangles [60].