ACE and acute respiratory distress syndrome: A reduced ratio of ACE-1/ACE-2 has been documented in ARDS; furthermore, experimentally ARDS and lung fibrosis can be prevented by administration of Ang(1-7) (Cao et al., 2019), or ARBs (Wösten-van Asperen et al., 2011), indicating that ACE-2 activation limits pulmonary disease progression.