In the bladder cancer, although there have been some reports on circular RNA, such as circ‐ITCH and circACVR2A suppresses bladder cancer progression by miR‐17/miR‐224/p21/PTEN and miR‐626/EYA4 axis, respectively23, 24; however, the global expression profile and precise molecular mechanism of BC‐specific circRNAs has not been well uncovered. This evidence concerns the gene PTEN and urinary bladder cancer.