Genes of fatty acid degradation, ketogenesis (HMGCS2), cholesterol metabolism (CYP7A1, CYP8B1, CYP27B1), steroid hormone synthesis, lipid transport (APOA1, APOA2 and APOA5) and carnitine shuttle were downregulated suggesting altered lipid metabolism in RCC. The gene discussed is CYP7A1; the disease is renal cell carcinoma.