Genes of fatty acid degradation, ketogenesis (HMGCS2), cholesterol metabolism (CYP7A1, CYP8B1, CYP27B1), steroid hormone synthesis, lipid transport (APOA1, APOA2 and APOA5) and carnitine shuttle were downregulated suggesting altered lipid metabolism in RCC. This evidence concerns the gene CYP8B1 and renal cell carcinoma.