Genes involved in the conversion of alanine to pyruvate (AGXT, AGXT2, and GPT), aspartate to L-arginino-succinate (ASS1), glutamine to glutamate (GLS), glutamate to α-ketoglutarate (GLUD2) and glutamate to succinate route (GAD, GABAT, SSADH) were downregulated in RCC. The gene discussed is GLUD2; the disease is renal cell carcinoma.