To assess the functional significance of CXXC5 through an augmented or a repressed level of CXXC5 synthesis in cell models derived from breast, or other tissues, adenocarcinomas, we used stable transfections with expression vectors bearing the CXXC5 cDNA or shRNA, the latter which was designed according to our previous study4. The gene discussed is CXXC5; the disease is adenocarcinoma.