PTEN and melanoma: Whether different classes of TP53 mutations alter immune infiltration in HGSOC remains unknown, but non-synonymous mutations in TP53 may have gain-of-function or other cellular effects distinct from loss-of-function mutations.16 Mutant p53 protein may drive B cell responses and auto-antibody production.17 Loss of PTEN expression in melanoma was associated with both reduced T cell infiltration and resistance to immune checkpoint inhibitors,18 but these associations have not been investigated in HGSOC.