Overall, the exact nature of the relationship between subtypes of TP53 mutations and immune infiltrate is still unclear and likely to vary across different cancers, as evidenced by two studies showing TP53 GOF mutations to be associated with pro-tumour effects related to inflammation in glioblastoma40 and immunosuppression in lung adenocarcinoma.41 The gene discussed is TP53; the disease is lung adenocarcinoma.