CAD and Klebsiella pneumonia: The Supplementary Fig. S2 shows the frequency of cps and kps in different genus-groups, demonstrating that the vast majority (92%) of genomes with kps also carried cps. The number of unique SP loci (i.e., comprising unique combinations of protein coding sequences, CDS) detected per genus was strongly predicted by sample size (number of genomes analysed per genus), but not the nucleotide diversity captured by that sample (see Supplementary Text S1 and Supplementary Fig. S3), consistent with recent observations in Klebsiella pneumonia [51].