While ANXA2 overexpression significantly shortened the survival of tumor-bearing mice compared with control mice (median survival = 94.5 days vs 101 days, P = 0.0094; Fig. 5a), concomitant silencing of OSMR significantly prolonged mouse survival (median survival = 131 or 137.5 days, both P = 0.0029; Fig. 5a). This evidence concerns the gene ANXA2 and neoplasm.