OSMR and neoplasm: Depletion of OSMR had similar effects; namely, it significantly prolonged mouse survival (median survival: 13.5 vs. 21.5 or 22 days, both P = 0.0058; Additional file 11: Supplementary Fig. S9A), eliminated tumor necrosis, and diminished tumor growth, proliferation, and vessel density (Additional file 11: Supplementary Fig. S9B and S9C).