Although the different expression pattern of P53 in A549 and H1299 cells and P53 acted as a tumor suppressor, we observed that hsa_circ_0000326 acted as a negative regulator of apoptosis, along with RAB14 overexpression in A549 and H1299 cells, which indicated P53 may not be the target for hsa_circ_0000326/miR-338-3p/RAB14 signal pathway. Here, RAB14 is linked to neoplasm.