To date, around 100 DUBs have been identified in humans and, based on structures, they are categorized into seven families: the ubiquitin-specific proteases (USPs), the ovarian tumor proteases (OTUs), the JAB1/MPN/MOV34 metalloproteases (JAMMs), the ubiquitin C-terminal hydrolases (UCHs), the Josephins, the motif interacting with ubiquitin (MIU)-containing novel DUB family (MINDYs), and ZUP1 [11]. This evidence concerns the gene ZUP1 and neoplasm.