KCNA3 and early-onset autosomal dominant Alzheimer disease: Among others, the voltage-gated potassium channel Kv1.3 was suggested as a marker for “classically” activated microglia in vitro upon stimulation with LPS or interferon-gamma [25], and in vivo data revealed a dramatically elevated expression of this channel in activated microglia of human brains with Alzheimer’s disease [52].