With regard to PD-L1 expression on tumor cells, the median OS was shorter in patients having tumors with high expression of PD-L1 (30.7 months; 95%CI: 12–not reached) than in patients having tumors with no expression of PD-L1 (44.0 months; 95%CI: 15–60), but the difference was without statistical significance (p = 0.3523, Fig. 5a). This evidence concerns the gene CD274 and neoplasm.