Moreover, focal adhesion kinase (FAK) signaling pathway was involved in integrin α5 (Huang et al. 2016) and integrin β1 (31)-mediated breast cancer metastasis, and integrin α5 and integrin β1 were related to PI3K/Akt signaling (Watabe et al. 2011). The gene discussed is AKT1; the disease is breast cancer.