Epigenetic inactivation via hypermethylation of promoter CpG island of TFPI2 is associated with TFPI2silencing in pancreatic ductal adenocarcinoma (Sato et al. 2005), gastric cancer (Takada et al. 2010), non-small-cell lung cancer (Rollin et al. 2005) and glioblastomas (Vaitkiene et al. 2012), and contributes to the aggressive phenotype of various tumors. This evidence concerns the gene TFPI2 and gastric cancer.