To further dissect the mechanism underlying the EMT process, we started to explore the role of lncRNAs and miRNAs such as HOTAIR and/or miR‐34a‐5p, which were reported to be involved in the EMT process in different cancer types 27, 30 In that, we examined the effect of BBR on the expressions of HOTAIR and miR‐34a‐5p and found that relative high expression levels of HOTAIR was observed in lung cancer cells (A549 and H1975) compared with that in the lung epithelial cells (BEAS‐2B) (Figure 3A). This evidence concerns the gene HOTAIR and cancer.