In consistent with this, metformin, an AMP‐activated protein kinase (AMPK) activator, diminished the extracellular signal‐regulated kinase (ERK) signalling by activation of AMPK pathway, and this led to suppression of snail resulting in up‐regulation of a tumour suppressor and critical EMT marker E‐cadherin by binding to the E‐cadherin promoter. This evidence concerns the gene SNAI1 and neoplasm.