Since the FACT histone chaperone complex can promote the resistance of tumor cells to DNA damage factors (Dejmek, Iglehart, & Lazaro, 2009; Koman et al., 2012; Yarnell, Oh, Reinberg, & Lippard, 2001), a follow‐up research is necessary to determine whether OTUD5 can reduce chemoradiotherapy resistance by antagonizing the FACT histone chaperone complex. Here, OTUD5 is linked to neoplasm.