For example, deubiquitinase otubain 1 regulates many cancer‐associated signaling pathways, including MAPK, mTORC1, and FOXM1, to promote cancer progression (Saldana, VanderVorst, Berg, Lee, & Carraway, 2019); the E3 ubiquitin ligase Hakai promoted the proliferation, metastasis, and chemoresistance of NSCLC cells (Liu, Wu, Tao, & Ma, 2018). This evidence concerns the gene CBLL1 and non-small cell lung carcinoma.