,64 In our GWAS on PDFF, alongside PNPLA3 and TM6SF2, we further identified variants in GCKR (another known NAFLD variant which we have replicated) and APOE (apolipoprotein E, a gene which encodes a major cholesterol carrier).63 The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.