PNPLA3 and cirrhosis of liver: Among 6 variants associated with all-cause cirrhosis in a recent GWAS of 5,770 cases and 572,850 controls,28 4 variants (those in or near MARC1, HSD17B13, TM6SF2 and PNPLA3) demonstrated associations with cT1 (Table 3), where alleles associated with higher risk of liver cirrhosis were also associated with higher cT1.