cT1-increasing alleles at 4 variants (in SLC30A10, SLC39A8, TM6SF2, and PNPLA3) were associated with higher ALT and AST (all with p values <2×10−5) and higher risk of type 2 diabetes (all with p <0.002, except the SLC30A10 variant). This evidence concerns the gene PNPLA3 and type 2 diabetes mellitus.