Other independent variants included an intronic variant (rs759359281-CA >C) in SLC30A10 (p = 2.8×10−8), a missense variant (rs111723834-G >A) in PCK2 (p = 3.0×10−11), a missense variant (rs4820268-A >G) in TMPRSS6 (p = 1.6×10−9), and 2 known cirrhosis variants (rs58542926-A >G) in TM6SF2 (p = 1.4×10−8) and (rs738409-C >G) in PNPLA3 (p = 9.6×10−13). The gene discussed is TMPRSS6; the disease is Cirrhosis.