They show that stimulated healthy T cells treated with the IgG serum fraction from SLE patients caused a reduction in IL‐2 expression by T cells from healthy patients, through increased expression of the IL‐2 suppressor cAMP response element modulator (CREM) indicating some level of TCR interference via IgG:CD3 binding [81]. This evidence concerns the gene IL2 and systemic lupus erythematosus.